β-Eudesmol
[2R-(2α,4aα,8aβ)]-Decahydro-8-methylene-α,α,4a-trimethyl-2-naphthylmethanol
β-Selinenol · Eudesm-4(14)-en-11-ol
化学組成 · Constituent
[2R-(2α,4aα,8aβ)]-Decahydro-8-methylene-α,α,4a-trimethyl-2-naphthylmethanol
β-Selinenol · Eudesm-4(14)-en-11-ol
化学組成 · Constituent
β-Eudesmol is a sesquiterpene alcohol occurring substantially in atractylis, araucaria, blue cypress and hinoki. The compound has pronounced bioactivity but dermal data are limited.
Oral. Acute oral LD50 in mice exceeds 2 g/kg.
Cardiovascular. β-Eudesmol displays considerable in vitro antiplatelet activity. It inhibits angiogenesis in granuloma tissue in mice at 0.90 mol/kg ip. The antiangiogenic activity suggests caution in pregnancy.
Liver. Significant hepatoprotective effects against carbon tetrachloride-induced cytotoxicity in rat hepatocytes.
Cancer. Inhibits in vitro growth of human liver cancer cells. Doses of 2.5 to 5.0 mg/kg suppress hepatoma and sarcoma growth in mice.
| Atractylis | 26.0 % |
| Araucaria | 25.9 % |
| Cypress (blue) | 14.4 % |
| Phoebe | 6.8 – 8.4 % |
| Valerian (European) | 0 – 8.3 % |
| Amyris | 3.2 – 7.9 % |
| Tansy (blue) | 3.5 – 6.7 % |
| Hinoki leaf | 6.5 % |
| Eucalyptus (smithii) | 6.3 % |
| Cypress (emerald) | 5.7 % |
| Vetiver | 0 – 5.2 % |
| Siam wood | 4.4 % |
| Arina | 2.2 % |
| Sanna | 2.2 % |
| Galangal (greater) | 0.4 – 1.1 % |
| Artemisia vestita | 1.0 % |
β-Eudesmol is a key constituent for the wood-green-tea profile of cypress varieties and Japanese hinoki, giving these oils their meditative, dry and quiet character.