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Isomenthone

2-(1-Methylethyl)-5-methylcyclohexanone

2-Isopropyl-5-methylcyclohexanone · p-Menthan-3-one

Monocyclic monoterpenoid ketone · C₁₀H₁₈O

Chemical structure of Isomenthone
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
491-07-6
Molecular formula
C₁₀H₁₈O
Molecular weight
154.25 g/mol
Aroma
Soft minty, with woody and honey facets, warm.

Safety

Low concern · Safe at standard use

Isomenthone is a monoterpenoid ketone isomeric with menthone, occurring substantially in pennyroyal, buchu, cornmint and peppermint.

Skin. An 8 percent patch test on 25 volunteers produced neither irritation nor sensitization.

Oral and dermal. Acute dermal LD50 in rats exceeds 5 g/kg.

Antioxidant. Significant radical scavenging activity against DPPH and OH.


Usage guidelines

Concern level
Low
Oils with high content
Pennyroyal, Buchu, Cornmint, Peppermint

Found in essential oils

Principal sources
Pennyroyal0.8 – 31.0 %
Buchu (diosphenol CT)4.6 – 29.1 %
Buchu (pulegone CT)3.6 – 27.6 %
Cornmint6.8 – 12.1 %
Geranium3.4 – 9.8 %
Peppermint2.0 – 8.7 %
Calamint (lesser)0 – 2.8 %
Cistus0 – 2.3 %

Pharmacokinetics

Isomenthol is the major and possibly the only urinary metabolite of isomenthone detected in rabbit urine.


Notes

Isomenthone is a secondary constituent in the Mentha family, contributing to the overall mint profile alongside menthone, menthol and pulegone.