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α-Cedrol

[3R-(3α,3aβ,6α,7β,8aα)]-Octahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulen-6-ol

3-Cedranol · Cedar camphor · Cypress camphor

Tricyclic sesquiterpenoid alcohol · C₁₅H₂₆O

Chemical structure of α-Cedrol
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
77-53-2
Molecular formula
C₁₅H₂₆O
Molecular weight
222.37 g/mol
Aroma
Warm cedarwood, mellow sweet, with a faint balsamic edge.

Safety

Low concern · Safe at standard use

α-Cedrol is an important sesquiterpene alcohol of Virginian, Texan and Himalayan cedarwood and cypress oils.

Skin. An 8 percent patch test on 25 volunteers caused no irritation or sensitization.

Oral and dermal. Rabbit dermal LD50 exceeds 5 g/kg.

Subchronic. Gavage at 8.4 mg/kg/day for 28 days in female rats reduced absolute brain weight and brain-to-body and ovary-to-body ratios, without associated clinical changes.

Anticancer. The compound inhibits growth of C32 melanoma and ACHN renal carcinoma cells with IC50 of 44.36 and 41.06 μg/mL.

Usage guidelines

Concern level
Low
Oils with high content
Virginian cedarwood 12.3–22.2 percent · Texan 12.2–19.1 percent

Found in essential oils

Principal sources
Cedarwood (Virginian)12.3 – 22.2 %
Cedarwood (Texan)12.2 – 19.1 %
Cypress2.0 – 7.0 %
Copaiba0 – 4.8 %
Cedarwood (Himalayan)1.3 %

Notes

Cedrol crystallizes at room temperature. The compound is the key carrier for the cedarwood base note in fine perfumery.