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Terpinyl acetate

α,α,4-Trimethylcyclohex-3-enylmethyl ethanoate

α-Terpinyl acetate · p-Menth-1-en-8-ol acetate · α-Terpineol acetate

Monocyclic monoterpenoid alkene ester · C₁₂H₂₀O₂

Chemical structure of Terpinyl acetate
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
80-26-2
Molecular formula
C₁₂H₂₀O₂
Molecular weight
196.29 g/mol
Aroma
Floral lavender, lightly fruity, sweet, softly woody, suggestive of cardamom.

Safety

Low concern · Safe at standard use

Terpinyl acetate, mainly the α isomer, is the principal constituent of cardamom and lovage leaf oils. The compound is safe at standard concentrations.

Skin. At 5 percent on 25 volunteers it was neither irritating nor sensitizing. At 10 percent mixed with 15 percent mixed isomer terpineol on 179 dermatitis patients suspected of cosmetic allergy, no reactions occurred. In 100 patients at 5 percent there were no reactions.

Oral. Acute oral LD50 in rats was 5.1 g/kg, a high value typical of low-toxicity compounds.

Subchronic. Rats fed 1,000, 2,500 or 10,000 ppm for 20 weeks showed no adverse effects.

Inhalation. Chronic terpinyl acetate vapor inhalation in animals causes changes in the central nervous system, blood and liver. The minimum active concentration is 10 mg/m3.


Usage guidelines

Concern level
Low
Maximum safe airborne concentration
10 mg/m3
Oils with high content
Lovage leaf 43 to 47 percent · Cardamom 29 to 40 percent

Found in essential oils

Principal sources
Lovage leaf43.4 – 47.3 %
Cardamon29.2 – 39.7 %
Sage (Spanish)0 – 15.5 %
Betel6.8 – 11.0 %
Hinoki leaf9.1 %
Hinoki root9.1 %
Lemon leaftr – 7.3 %
Laurel leaf4.5 – 7.0 %
Cypress4.1 – 6.4 %
Juniper (Phoenician)0 – 4.6 %
Myrtle0 – 4.4 %
Lovage seed3.1 %
Thuja1.0 – 1.8 %

Notes

α-Terpinyl acetate plays a central role in the sweet floral character of cardamom and is a widely used ester in perfumery.