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Sclareolide

(3aR,5aS,9aS,9bR)-3a,6,6,9a-Tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-one

Sclareolide, Norambreinolide

Labdane-derived lactone · C₁₆H₂₆O₂

Chemical structure of Sclareolide
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
564-20-5
Molecular formula
C₁₆H₂₆O₂
Molecular weight
250.38 g/mol
Origin
Nature-identical
Odor family
Amber
Note
Base
Aroma
Weak odor, dry amber with woody and tobacco nuances.

History

Sclareolide is the lactone obtained by oxidising sclareol from clary sage. In the classic ambroxide process it is the intermediate: it is reduced to a diol, which is then cyclised to ambroxide.

In perfumery

Sclareolide is used as an amber fixative and in tobacco flavors. Its main role is as an intermediate in ambroxide production.

Connections

Evokestobacco
Found in natureClary sage (Salvia sclarea)

Regulatory status

Unrestricted · No IFRA standard
IFRA 51
No dedicated IFRA Standard in the 51st Amendment index.
EU allergen 2023/1545
Not named individually in the expanded allergen list of Regulation 2023/1545.

Sources

  1. NCI/CADD Chemical Identifier Resolver, CAS 564-20-5 (formula, names)
  2. Sell C.S. (ed.) The Chemistry of Fragrances: From Perfumer to Consumer, 2nd ed., Royal Society of Chemistry 2006
  3. The Good Scents Company Information System, material entries
  4. IFRA Standards, 51st Amendment: Index of IFRA Standards (notified 30 June 2023)