3-Butyl phthalide · Constituent

Chemical info / 化学情報

CAS number CAS

6066-49-5

Molecular formula

C₁₂H₁₄O₂

Molecular weight

190.24 g/mol

Aroma

Pronounced celery, savory, with a faintly bitter finish.

Safety / 安全性

Low concern · Safe at standard use

3-Butyl phthalide is the characteristic phthalide of celery leaf and seed oils. Data indicate low risk.

Skin. Undiluted application to rabbit skin under occlusion for 24 hours was moderately irritating. A 2 percent patch test on 30 volunteers gave no irritation or sensitization.

Oral. Acute oral LD50 in rats is 2.45 g/kg; rabbit dermal LD50 exceeds 5 g/kg.

Cancer. The compound induces glutathione S-transferase in mouse liver and small intestine and reduces forestomach cancer incidence.

Usage guidelines / 使用基準

Concern level

Low

Oils with high content

Celery leaf 6.2 percent · Celery seed 2.1–3.0 percent

Found in essential oils / 含有精油

Principal sources
Celery leaf	6.2 %
Celery seed	2.1 – 3.0 %

Notes / 注記

Phthalides such as 3-butyl phthalide are botanical markers for the Apiaceae family. They define the celery note in perfumery and food flavoring.