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Musk ambrette

1-tert-Butyl-2-methoxy-4-methyl-3,5-dinitrobenzene

Musk ambrette, 6-tert-Butyl-3-methyl-2,4-dinitroanisole

Nitro musk · C₁₂H₁₆N₂O₅

Chemical structure of Musk ambrette
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
83-66-9
Molecular formula
C₁₂H₁₆N₂O₅
Molecular weight
268.27 g/mol
Introduced
early 1890s · Albert Baur
Origin
Synthetic
Odor family
Musk
Note
Base
Aroma
Sweet, warm musk reminiscent of ambrette seed (historical description).

History

Musk ambrette was described by Albert Baur in the early 1890s and was once very popular in men's fragrance and shaving products. From the 1980s it was linked to photosensitivity reactions on skin and to neurotoxicity in animal tests.

IFRA issued a Prohibition Standard, dated 2006 in the 51st Amendment index. The EU lists musk ambrette in Annex II (substances prohibited in cosmetics).

In perfumery

Musk ambrette is no longer used. The ambrette-seed effect is now built with ambrettolide and macrocyclic musks.

Connections

Evokesambrette seed

Regulatory status

Photosensitizer · IFRA + EU prohibited
IFRA 51
Prohibition (Prohibition Standard, published 2006).
EU CosReg
Annex II, entry 414: prohibited in cosmetics.
EU allergen 2023/1545
Not named individually in the expanded allergen list of Regulation 2023/1545.

Sources

  1. NCI/CADD Chemical Identifier Resolver, CAS 83-66-9 (formula, names)
  2. IFRA Standards, 51st Amendment: Index of IFRA Standards (notified 30 June 2023)
  3. Regulation (EC) No 1223/2009 on cosmetic products, Annexes II and III
  4. Sell C.S. (ed.) The Chemistry of Fragrances: From Perfumer to Consumer, 2nd ed., Royal Society of Chemistry 2006