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Versalide

1-(3-Ethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

Versalide, AETT, Acetyl ethyl tetramethyl tetralin

Polycyclic musk (tetralin) · C₁₈H₂₆O

Chemical structure of Versalide
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
88-29-9
Molecular formula
C₁₈H₂₆O
Molecular weight
258.40 g/mol
Origin
Synthetic
Odor family
Musk
Note
Base
Aroma
Sweet, warm, lightly woody musk (historical description).

History

Versalide (AETT) was once widely used in perfume and cosmetics. In 1979 Spencer and colleagues reported in Science that AETT caused nerve damage and organ discoloration in rats. The supplier stopped selling it in the late 1970s.

IFRA issued a Prohibition Standard for AETT; the 51st Amendment index gives 2006 as its publication year.

In perfumery

Versalide is no longer used in fragrance. It is cited as a historical case of a molecule withdrawn after toxicity data emerged.

Regulatory status

Neurotoxic · IFRA + EU prohibited
IFRA 51
Prohibition: must not be used as a fragrance ingredient (Prohibition Standard, published 2006).
EU CosReg
Annex II, entry 362 (AETT; Versalide): prohibited in cosmetics.
EU allergen 2023/1545
Not named individually in the expanded allergen list of Regulation 2023/1545.

Sources

  1. NCI/CADD Chemical Identifier Resolver, CAS 88-29-9 (formula, names)
  2. Spencer P.S. et al. Neurotoxic fragrance produces ceroid and myelin disease. Science 204 (1979) 633–635
  3. IFRA Standards, 51st Amendment: Index of IFRA Standards (notified 30 June 2023)
  4. Sell C.S. (ed.) The Chemistry of Fragrances: From Perfumer to Consumer, 2nd ed., Royal Society of Chemistry 2006