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Tonalide

1-(3,5,5,6,8,8-Hexamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one

Tonalide, Fixolide, AHTN, Musk tonalid

Polycyclic musk (tetralin) · C₁₈H₂₆O

Chemical structure of Tonalide
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
21145-77-7
Molecular formula
C₁₈H₂₆O
Molecular weight
258.40 g/mol
Origin
Synthetic
Odor family
Musk
Note
Base
Aroma
Sweet, warm musk with powdery and woody facets, very tenacious.

History

Tonalide (AHTN) is a tetralin-type polycyclic musk from the same period as galaxolide, part of the musks that replaced nitro musks. AHTN and HHCB together once accounted for most of the world's synthetic musk volume.

Like HHCB, AHTN persists in the environment and has been assessed several times by the EU Scientific Committee on Consumer Safety (SCCS).

In perfumery

Tonalide is used as a musk base and fixative in perfume, cosmetics and detergents, often together with galaxolide.

Regulatory status

EU Annex III limits · Environmentally persistent
IFRA 51
No dedicated IFRA Standard in the 51st Amendment index.
EU CosReg
Annex III, entry 182 (AHTN, CAS 21145-77-7 / 1506-02-1), all products except oral: leave-on 0.1%, except hydroalcoholic products 1%, fine fragrance 2.5%, fragrance cream 0.5%; rinse-off 0.2%.
EU allergen 2023/1545
Not named individually in the expanded allergen list of Regulation 2023/1545.

Sources

  1. NCI/CADD Chemical Identifier Resolver, CAS 21145-77-7 (formula, names)
  2. Sell C.S. (ed.) The Chemistry of Fragrances: From Perfumer to Consumer, 2nd ed., Royal Society of Chemistry 2006
  3. The Good Scents Company Information System, material entries
  4. IFRA Standards, 51st Amendment: Index of IFRA Standards (notified 30 June 2023)