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Isobornyl acetate

exo-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl ethanoate

exo-Bornanyl acetate · exo-2-Camphanyl acetate · Acetic acid isobornyl ester

Bicyclic monoterpenoid ester · C₁₂H₂₀O₂

Chemical structure of Isobornyl acetate
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
125-12-2
Molecular formula
C₁₂H₂₀O₂
Molecular weight
196.29 g/mol
Aroma
Fresh pine, lightly camphoraceous, like coniferous forest after rain.

Safety

Low concern · Caution at high oral dose

Isobornyl acetate is the dominant constituent in hemlock spruce oil. Isomeric with bornyl acetate.

Skin. Applied undiluted to rabbit skin, it was mildly irritating. A 10 percent patch test on 25 volunteers produced no sensitization. At 5 percent on 100 consecutive dermatitis patients, no irritation or allergic reactions occurred.

Oral and dermal. Acute oral LD50 in rats exceeds 10 g/kg. Acute dermal LD50 in rabbits exceeds 20 g/kg, a very high level.

Subchronic. A 90-day rat gavage study at 15, 90 or 270 mg/kg showed signs of nephrotoxicity at the two higher doses. The NOAEL was 15 mg/kg/day.

Usage guidelines

Concern level
Low for topical, note kidney toxicity at high oral doses
90-day NOAEL
15 mg/kg/day
Oils with high content
Spruce (hemlock) 34.7 percent

Found in essential oils

Principal sources
Spruce (hemlock)34.7 %

Notes

Isobornyl acetate contributes a pine-forest note to hemlock spruce and other spruce oils. It is widely used in men's fragrance and household products.