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Dimethyl anthranilate

Methyl 2-methylaminobenzoate

Methyl N-methylanthranilate

Benzenoid amine ester · C₉H₁₁NO₂

Chemical structure of Dimethyl anthranilate
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
85-91-6
Molecular formula
C₉H₁₁NO₂
Molecular weight
165.19 g/mol
Aroma
Grape-blossom sweet, lightly honeyed, with mandarin peel facets.

Safety

Phototoxic · IFRA restricted

Dimethyl anthranilate is the principal constituent of mandarin leaf oil. The compound is phototoxic and is specifically restricted by IFRA.

Skin. Applied undiluted to rabbit skin, it was non-irritating. A 10 percent patch test on humans showed no irritation or sensitization. However, it was phototoxic in 8 of 10 volunteers at 5.0 percent. The NOAEL for phototoxicity is 0.5 percent. It did not cause photoallergy at 5.0 percent.

Oral and dermal. Acute oral LD50 in rats is 2.25 to 3.38 g/kg. Acute dermal LD50 in rabbits exceeds 5 g/kg.

Subchronic. A 12-week rat study established a NOAEL of 20.3 mg/kg.

Usage guidelines

Regulatory status
IFRA limits to 0.1 percent in products applied to sun-exposed skin
Phototoxicity
Yes, NOAEL 0.5 percent
Oils with high content
Mandarin leaf 43.2 – 51.9 percent

Found in essential oils

Principal sources
Mandarin leaf43.2 – 51.9 %

Notes

Mandarin leaf oil is used in perfumery for delicate orange blossom notes. Due to phototoxicity, the oil is concentration-limited in products applied to sun-exposed skin.