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β-Cedrene

[3R-(3α,3aβ,7β,8aα)]-Octahydro-3,8,8-trimethyl-6-methylene-1H-3a,7-methanoazulene

8(15)-Cedrene · Cedr-8(15)-ene

Tricyclic sesquiterpenoid alkene · C₁₅H₂₄

Chemical structure of β-Cedrene
2D structure PubChem / NCI CIR

Chemical info

CAS number CAS
546-28-1
Molecular formula
C₁₅H₂₄
Molecular weight
204.35 g/mol
Aroma
Cedarwood, softer than α-cedrene, dry, faintly fresh.

Safety

Low concern · Possible drug interaction with opioids

β-Cedrene shares its toxicity profile with α-cedrene. Cedrene (unspecified isomer) by intraperitoneal, oral or inhalation routes significantly induces CYP and ethylmorphine N-demethylase, with potential to interact with opioids.

Oral 200 mg/kg/day for three days increased ethylmorphine metabolism by 160 percent and CYP by 40 percent. Inhalation 60 mg/kg/day for 2–6 days raised EMND by 180 percent.

Direct acute toxicity and skin sensitization data are sparse, but structural similarity to α-cedrene does not raise specific safety flags.


Usage guidelines

Concern level
Low
Drug interactions
May reduce opioid effect through EMND induction

Found in essential oils

Principal sources
Cedarwood (Virginian)8.2 – 9.2 %
Cedarwood (Texan)5.5 %
Hinoki leaf4.7 %
Cedarwood (Himalayan)1.4 %

Notes

β-Cedrene is the minor isomer in cedarwood oils. The compound is typically analyzed alongside α-cedrene as an oil quality marker.